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The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, <strong>Design and Analysis of Non-Inferiority Trials</strong> brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Each chapter begins with a non-technical introduction, making the text easily understood by those without prior knowledge of this type of trial. <strong>Topics covered include: </strong> A variety of issues of non-inferiority trials, including multiple comparisons, missing data, analysis population, the use of safety margins, the internal consistency of non-inferiority inference, the use of surrogate endpoints, trial monitoring, and equivalence trials Specific issues and analysis methods when the data are binary, continuous, and time-to-event The history of non-inferiority trials and the design and conduct considerations for a non-inferiority trial The strength of evidence of an efficacy finding and how to evaluate the effect size of an active control therapy A comprehensive discussion on the purpose and issues involved with non-inferiority trials, <strong>Design and Analysis of Non-inferiority Trials</strong> will assist current and future scientists and statisticians on the optimal design of non-inferiority trials and in assessing the quality of non-inferiority comparisons done in practice.
Acquisto del libro
Design and Analysis of Non-Inferiority Trials, Ivan S.F. Chan, Brian L. Wiens, Mark Rothmann
- Lingua
- Pubblicato
- 2009
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- (Copertina rigida)
Metodi di pagamento
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- Titolo
- Design and Analysis of Non-Inferiority Trials
- Lingua
- Inglese
- Editore
- Chapman and Hall/CRC
- Pubblicato
- 2009
- Formato
- Copertina rigida
- Pagine
- 438
- ISBN10
- 1584888040
- ISBN13
- 9781584888048
- Serie
- Tag
- Saggistica, Scienza e Matematica, Scienze Naturali, Biologia, Scienza, Matematica, Medicina, Droghe, Ricerca, Farmacologia
- Descrizione
- The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, <strong>Design and Analysis of Non-Inferiority Trials</strong> brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Each chapter begins with a non-technical introduction, making the text easily understood by those without prior knowledge of this type of trial. <strong>Topics covered include: </strong> A variety of issues of non-inferiority trials, including multiple comparisons, missing data, analysis population, the use of safety margins, the internal consistency of non-inferiority inference, the use of surrogate endpoints, trial monitoring, and equivalence trials Specific issues and analysis methods when the data are binary, continuous, and time-to-event The history of non-inferiority trials and the design and conduct considerations for a non-inferiority trial The strength of evidence of an efficacy finding and how to evaluate the effect size of an active control therapy A comprehensive discussion on the purpose and issues involved with non-inferiority trials, <strong>Design and Analysis of Non-inferiority Trials</strong> will assist current and future scientists and statisticians on the optimal design of non-inferiority trials and in assessing the quality of non-inferiority comparisons done in practice.