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Heteroaromatic Lipoxin A4 Analogues
Synthesis and Biological Evaluation
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Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Lingua
- Pubblicato
- 2012
- Rilegatura
- (Copertina rigida)
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- Titolo
- Heteroaromatic Lipoxin A4 Analogues
- Sottotitolo
- Synthesis and Biological Evaluation
- Lingua
- Inglese
- Autori
- Colm Duffy
- Editore
- Springer Berlin Heidelberg
- Pubblicato
- 2012
- Formato
- Copertina rigida
- Pagine
- 152
- ISBN13
- 9783642246319
- Serie
- Springer Theses
- Categoria
- Tag
- Descrizione
- Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.