Questa serie si addentra nelle profondità dello spazio, dove l'umanità stabilisce il primo contatto con l'intelligenza aliena attraverso segnali misteriosi. La conoscenza scoperta, decifrata da un computer extraterrestre, apre un vaso di Pandora della comprensione umana. La scienza e la tecnologia vengono spinte ai loro limiti, ma affrontano anche una minaccia che potrebbe mettere in pericolo la stessa esistenza dell'umanità.
A new radio telescope picks up from the constellation of Andromeda a complex series of signals which prove to be a programme for a giant computer. After the computer is built it begins to relay information from Andromeda. Scientists find themselves possessing knowledge previously unknown to mankind, knowledge that could threaten the security of human life itself.
The Andromeda Breakthrough is a sequel to the popular BBC TV science fiction serial A for Andromeda, written by Fred Hoyle and John Elliot. Kidnapped by Intel, John Fleming, the hero of the first serial, and Andromeda, the artificially constructed human, are brought to Azaran, a small Middle Eastern country, where a duplicate of the machine he designed has been built by Intel. After many dangers, he finds both the reason for the original message having been sent and the means to bring the machine under human control.