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Informatics and robotics drive a technological revolution in drug research, underpinning combinatorial chemistry that produces thousands of compounds and high-throughput bioassays that screen them for activity. This results in an overwhelming number of 'hits' that populate databases. However, these compounds can be advantageous if properly evaluated for 'drugability', focusing on 'drug-like' properties such as pharmacokinetic (PK) behavior. PK profiling of bioactive compounds is essential for identifying the most promising candidates. Additionally, the less visible structure-property and structure-ADME relationships that arise from PK profiling provide valuable insights for designing new synthetic series. The book emphasizes the profiling of ADME properties (absorption, distribution, metabolism, and excretion) and highlights significant advancements in biological, physicochemical, and computational strategies in recent years. Contributions from international authorities and experts from academia and industry present cutting-edge concepts, methods, and technologies currently in use or under development in drug research. The work includes 28 chapters and a CD-ROM featuring invited lectures, oral communications, and posters from the Third LogP Symposium on 'Physicochemical and Biological Profiling in Drug Research,' held at ETH Zurich in March 2004.
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Pharmacokinetic profiling in drug research, Bernard Testa
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- 2005
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