Optimized response-adaptive clinical trials

Sequential Treatment Allocation Based on Markov Decision Problems

Autori

• Thomas Ondra

Parametri

• 117 pagine
• 5 ore di lettura

• Matematica

Maggiori informazioni sul libro

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

Lingua: Inglese

Pubblicato: 2015

(In brossura)