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The ability to remember past events is one of the most remarkable talents of the human brain, with the hippocampus playing a crucial role in transforming new experiences into long-term memory. Its neurons have two specialized extensions for directed information processing: widely branched dendrites that receive input and a single axon that transmits output to other cells. Typically, both structures arise directly from the cell body. However, our research reveals that in many hippocampal neurons, the axon originates from one of the dendrites. This study focuses on characterizing this unique anatomy and its impact on neuronal signal processing. By employing techniques such as immunohistochemistry, electrophysiology, and computer simulations, we demonstrated that these axon-carrying dendrites form a privileged channel for excitatory synaptic input. This mechanism provides new avenues for information processing within the hippocampus and enhances our understanding of the biophysical foundations of memory formation. Our findings highlight the significance of this anatomical phenomenon, showcasing how it influences the strength and network behavior of signals, thereby contributing to the intricate processes of learning and memory.
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Axon-carrying dendrites, Christian Thome
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- 2017
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