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The book delves into the development of HIV protease inhibitors as crucial antiviral agents in the fight against AIDS, particularly in response to drug resistance to reverse transcriptase inhibitors. It highlights the synthesis and market introduction of key protease inhibitors like saquinavir, ritonavir, indinavir, and nelfinavir. The text also covers the structure-activity relationship of saquinavir and related compounds, the significance of HIV protease as a therapeutic target, and prospects for future anti-HIV drug development.
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Progress in Drug Research, Ernst Jucker
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- Pubblicato
- 2011
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