Dhaval B. Patel Libri

Focused on the synthesis of quinoline hybrid thiosemicarbazide derivatives using microwave irradiation, the book details their application in biological studies. The compounds showed promising results in docking studies, fitting well within protein cavities and achieving excellent G-scores. Additionally, molecular dynamics studies, pharmacophore analysis, and ADME-Tox evaluations were conducted to assess drug-likeness properties. The findings suggest that these synthesized molecules have potential as future hit compounds in drug discovery.

The book presents a pioneering approach to synthesizing ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives using water and ethanol as solvents, with urea as a novel catalyst. It highlights the efficiency of this method, achieving high yields in a short reaction time. Additionally, the findings indicate that aromatic aldehydes with electron-withdrawing groups yield better results and require less time compared to those with electron-donating groups, showcasing the significance of substituent effects in the synthesis process.

The book details a novel one-pot multi-component reaction (MCR) utilizing ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives, catalyzed by urea in a water-ethanol system. It highlights the efficiency of the reaction involving aldehydes, malononitrile, and ethylacetoacetate at room temperature, yielding products with minimal effort. The synthesized compounds are thoroughly validated using Mass, 1H-NMR, IR, and melting point analysis. The method is noted for its mild conditions, high yields, and the reusability of the reaction media, emphasizing its eco-friendly approach.

The book explores a series of novel fluorine-containing quinoline hybrid thiosemicarbazide analogues, emphasizing their synthesis and medicinal chemistry applications. It details in-vitro studies demonstrating the compounds' effectiveness against various strains, including antibacterial, antifungal, antimalarial, and antituberculosis. The research highlights the potential of N-based heterocyclic compounds in providing significant biological activity, contributing to the development of effective new drugs.

The book details the synthesis of a series of new thiosemicarbazide derivatives based on 2-(2-chlorophenyl)quinoline-4-carboxylic acid, achieved with excellent yields. Characterization of these compounds was performed using various spectral methods, including 1H NMR, 13C NMR, mass spectrometry, and IR analysis, alongside physical studies like melting points. The biological activity of the newly synthesized compounds was evaluated, revealing promising results compared to a standard drug.

The book presents a novel series of thiosemicarbazide derivatives derived from 2-(2-chlorophenyl)quinoline-4-carboxylic acid, detailing their physical and spectral characterization, including melting points and mass analysis. It explores the antibacterial and antifungal activities of these compounds, revealing that several exhibit significant effectiveness against various strains. This research contributes to the understanding of potential new antimicrobial agents.

Focusing on the synthesis and biological evaluation of novel quinoline derivatives, this work highlights the design of 2-(2-chlorophenyl)quinoline-4-carboxylic acid hybrid thiosemicarbazides. The compounds showed significant in-vitro activity against gram-positive bacteria, outperforming gram-negative strains. Promising ADME-Tox parameters indicate favorable pharmacokinetics, suggesting their potential as drug development leads. Additionally, molecular dynamics simulations support the feasibility of these compounds as effective biological agents and inhibitors in future drug research.

The book presents a green and efficient one-pot microwave irradiation method for synthesizing quinoline-4-carboxylic acids using the non-hazardous p-TSA catalyst. This protocol boasts high product yields and purity, significantly reduced reaction times, and eliminates hazardous solvents, aligning with green chemistry principles. It details the synthesis of compounds 4a-4p and their biological activity testing, with molecular docking studies indicating their compatibility with protein active sites. Compound 4c was highlighted for further molecular dynamics analysis.

Neue fluorhaltige Chinolin-Hybrid-Thiosemicarbazid-Analoga und deren In-vitro-Untersuchung in antibakteriellen, antimykotischen, antimalariellen und antituberkulösen Stämmen. Die Analoga waren gegen den Malariastamm Plasmodium falciparum aktiv, wobei die Analoga 8d, 8g, 8h, 8k und 8l eine bemerkenswerte Aktivität gegenüber dem Referenzmedikament Chinin zeigten. Wir haben Molekulares Docking, ADME-Tox, Molekulardynamik und Pharmakophor-Studie durchgeführt. Die biologische Aktivität und die molekulare Docking-Studie wurden für die potenten Moleküle korreliert. In dieser Studie wurden die aktiven Bindungsstellen der Analoga vorgeschlagen, um einen optimalen Mechanismus in der In-silico-Seite zu finden. Dann wurde für das aktivste Molekül 8g eine Molekulardynamikstudie durchgeführt. Dieser Artikel kommt zu dem Schluss, dass die Analoga 8d, 8g und 8k eine vielversprechende Spur für die neue Entwicklung von Malariatherapeutika darstellen.