David A. Jans Libri

Exploring the Mobile Receptor Hypothesis, this book delves into the dynamics of biological membranes and the lateral mobility of receptors, crucial for signal transduction. It covers various methodologies for measuring protein mobility, the factors influencing it, and the implications of receptor movement in hormonal responses and GTP-binding protein interactions. The text emphasizes the role of the cytoskeleton and discusses potential pharmacological applications, providing a comprehensive view of how receptor mobility affects cellular communication and function.

Methods and Protocols highlights the numerous molecular, cellular and in vivo tools now available to conduct human rhinovirus (HRV) research in an effort to increase understanding of the clinical disease caused by HRVs as well as the functions of its individual proteins and its replication. Human rhinoviruses are the major cause of common colds as well as being more recently recognized as the major viral cause of asthma and chronic obstructive pulmonary disease (COPD) exacerbations. The huge advancements in technical applications of biophysics and improvements in high-end imaging techniques have also had implications for HRV research among other infectious diseases. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Methods and Protocols seeks to serve both professionals and novices with the latest technical advances in HRV research to ultimately enable the development of therapeutic approaches to combat HRV, and most importantly, its pathogenic effects in asthma exacerbation.

The Fluid Mosaic model of biological membranes, formulated over 20 years ago, implies that receptors float freely within the plane of the membrane. This book is a critical exposition of the theory behind and evidence for the mobile receptor hypothesis. It treats the direct evidence for the mobile receptor hypothesis with particular respect to tyrosine kinase receptors such as those for insulin and epidermal growth factor, and the GTP-binding protein activating V1- and V2-type receptors for vasopressin.