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Chronic viral hepatitis is a leading cause of disease and death globally. Hepatitis B virus (HBV) and hepatitis C virus (HCV) present significant challenges due to their unique replication methods and interactions with the host immune system. While antiviral therapy exists for chronic HBV, the rise of viral resistance necessitates the development of new chemotherapeutic agents. The absence of effective cell culture systems for HCV and suitable small-animal models has hindered antiviral drug development. However, promising new agents targeting HCV are currently in preclinical and clinical stages. This monograph offers a comprehensive overview of Hepatitis Prevention and Treatment, featuring contributions from leading experts in viral hepatitis. It addresses the molecular biology, immunology, biochemistry, pharmacology, and clinical aspects of chronic HBV and HCV infections. Key topics include the history and epidemiology of both viruses, recent findings on viral replication mechanisms, the host immune response, vaccine development for HBV and HCV, current standards of care for patients, and emerging therapies alongside challenges associated with existing antiviral treatments. The text provides valuable insights for researchers and clinicians while also offering foundational knowledge for newcomers to the field.
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Hepatitis Prevention and Treatment, Joseph M. Colacino
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- Pubblicato
- 2012
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- (In brossura)
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