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An estimated half of all drug molecules in medicine are administered as salts, making the formation and selection of suitable salts a crucial step in preclinical drug development. Despite this importance, scientific literature on the topic is limited and scattered across various journals and patents. Many medicinal chemists, primarily organic chemists focused on designing novel compounds, often treat salt formation as a minor activity aimed at obtaining crystalline material. This oversight can lead to missed opportunities for enhancing efficacy and drug delivery through optimal salt selection. To address this gap, an international team of seventeen authors from academia and the pharmaceutical industry has compiled a resource that covers the preparation, selection, and use of pharmaceutically active salts. The introductory chapter reviews the objectives in pursuing these salts, followed by discussions on the theoretical foundations of salt formation, solid-state properties, and safety and biopharmaceutical aspects. Practical applications in industrial research and development, regulatory issues, and examples of salt preparation are also included. The book concludes with a comprehensive compilation of salt-forming acids and bases, making it an essential reference for students and professionals in medicinal and pharmaceutical chemistry, as well as for those involved in drug development.
Acquisto del libro
Handbook of pharmaceutical salts, Peter Heinrich Stahl
- Lingua
- Pubblicato
- 2008
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