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Droplets are essential in various fields, including pharmaceutics, food technology, and chemical processing, serving as templates for polymeric spheres or capsules, and playing a role in operations like liquid-liquid extraction and drug delivery. Controlling the size, shape, and distribution of these droplets is crucial for product quality. This thesis introduces a novel technology for droplet generation using porous-wall channels, which can be either hollow-fiber membranes or embedded channels in flat-sheet membranes. In this method, two immiscible phases flow together, causing the inner phase to break into droplets through either dripping or jetting, influenced by the dominant forces. The mechanics of droplet formation are explored through experimental methods and CFD simulations. Additionally, a design for generating droplets in the low micron range is proposed. The technology's potential applications are examined, particularly using commercially available hollow-fiber membranes for generating aqueous two-phase systems (ATPS) droplets, droplet solidification, elongated particle formation, and liquid-liquid extraction, with the latter showing the most promising results.
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Principles and applications of droplet formation in porous-wall channels, Hans F. Breisig
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- 2017
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