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Aging is linked to various diseases such as type 2 diabetes, hypertension, and cancer, yet our understanding of the aging process remains limited. This study investigates the effects of dietary L-carnitine on aging in mice, focusing on its role in facilitating the import of long-chain fatty acids into mitochondria for β-oxidation, as well as its influence on glucose metabolism and insulin sensitivity. Given that carnitine status declines with age, supplementation may enhance metabolism and mitigate age-related diseases. The research tested two hypotheses: (1) Carnitine supplementation improves the carnitine status of aging mice, and (2) this improvement alters metabolic and stress signaling pathways in older tissues. Eighty male mice were divided into two groups: a control group receiving a low-carnitine diet and a carnitine group receiving the same diet supplemented with L-carnitine. At various ages (9, 15, 18, and 21 months), tissue samples were collected for analysis. Results showed that carnitine supplementation significantly increased plasma and tissue carnitine concentrations. Additionally, at 9 months, higher mRNA levels of key metabolic genes were observed in the carnitine group, with further upregulation noted at 18 months. Microarray analysis revealed 326 differentially expressed genes in skeletal muscle, including apoptotic genes. Overall, L-carnitine supplementation enhances carnitine status in aging mice, correla
Acquisto del libro
The effect of long term carnitine supplementation on carnitine status and metabolic pathways of mice during aging, Uzman Bashir Cheema
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- Pubblicato
- 2017
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