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Peripheral nerve injuries can impair sensory, motor, and autonomic functions. Neurotmesis, a severe nerve injury, may lead to neuropathic pain. Research indicates that axotomy and capsaicin treatment reduce primary afferent neuron sensitivity through TRPV1 receptor downregulation, with distinct cellular mechanisms influencing TRPV1 mRNA expression based on injury type.
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Capsaicin and Pain. Morphological and phenotypic changes after neurotmesis and perineural capsaicin treatment, Csaba Szigeti, Péter Sántha
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- 2013
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