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Frozen-hydrated specimens are central to low-temperature microscopy, enabling scientists to capture and analyze biological structures in their native state. This book provides an in-depth exploration of techniques for rapid freezing and specimen preparation, highlighting the significance of preserving dynamic events at the moment of trapping. It emphasizes the necessity of this approach in electron microscopy, where enhanced resolution allows for detailed investigation of organelles, macromolecules, and ions, thus addressing the challenges faced by researchers in the field.
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Low-Temperature Microscopy and Analysis, Patrick Echlin
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- 2013
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