Fabrication of interpenetrating polymer network hydrogel microspheres

Formulation optimization of cinnarizine loaded chitosan/methylcellulose microspheres using response surface methodology

Autori

• Pradeep Kumar

Parametri

• 140 pagine
• 5 ore di lettura

• Salute & Medicina

Maggiori informazioni sul libro

The research focuses on developing mucoadhesive hydrogel microspheres for controlled drug release using cinnarizine, chitosan, and methylcellulose. It explores drug delivery systems through polymer complexes and hydrogel networks while emphasizing gastroretention and bioadhesion for weakly basic drugs. The study employs response surface methodology to optimize various parameters, demonstrating that a two-factor central composite design effectively addresses nonlinear responses in drug delivery systems. Results suggest that interpenetrating polymer networks are promising for enhancing the delivery of weakly basic medications.

Lingua: Inglese

Pubblicato: 2011

(In brossura)