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The first edition of this handbook successfully compiled limited and scattered scientific literature on pharmaceutically active salts, creating a comprehensive resource for their preparation, selection, and use. This revised edition responds to ongoing interest in the topic, featuring contributions from an international team of authors from both academia and the pharmaceutical industry, reflecting the multidisciplinary nature of salt selection for new drug products. It offers theoretical foundations alongside practical insights into choosing pharmaceutically active salts, addressing all aspects of salt preparation. An introductory chapter reviews various objectives in pursuing these salts, followed by a discussion on the theoretical background of salt formation. Subsequent chapters cover the practice of salt formation in industrial R&D, as well as regulatory and patent considerations. Practical examples are provided for lab practitioners, and the book concludes with an annotated compilation of individual salt-forming acids and bases, including their properties. An appendix features tables of acids and bases sorted alphabetically and by pKa, along with additional useful information. This essential reference is invaluable for students and professionals in medicinal and pharmaceutical chemistry, serving as a critical guide for R&D chemists, analytical chemists, biologists, development pharmacists, and medicinal scientists involve
Acquisto del libro
Handbook of pharmaceutical salts, Peter Heinrich Stahl
- Lingua
- Pubblicato
- 2011
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