Synthesis and Computational Applicaton of Quinoline

DE

Autori

• Dhaval B. Patel

Parametri

• 56 pagine
• 2 ore di lettura

• Chimica
• Scienze Naturali

Maggiori informazioni sul libro

Focusing on the synthesis and biological evaluation of novel quinoline derivatives, this work highlights the design of 2-(2-chlorophenyl)quinoline-4-carboxylic acid hybrid thiosemicarbazides. The compounds showed significant in-vitro activity against gram-positive bacteria, outperforming gram-negative strains. Promising ADME-Tox parameters indicate favorable pharmacokinetics, suggesting their potential as drug development leads. Additionally, molecular dynamics simulations support the feasibility of these compounds as effective biological agents and inhibitors in future drug research.

Lingua: Inglese

Pubblicato: 2023

(In brossura)