Reinhard Kramer Libri

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.

Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Kramer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.

„Seychellen – Sehnsucht nach dem Paradies“ ist Titel und Leitmotiv dieses etwas anderen Reiseführers. In kurzen Etappen führt der Autor durch diese zauberhafte Inselwelt und lässt reflektierend hinter den kleinen Erlebnissen ihren tieferen Charakter sichtbar werden. Dabei kontrastiert er den an vielen Orten noch aufscheinenden paradiesischen Urzustand mit den Widersprüchen der Realität, dem Alltagsleben und dem Kampf um die Bewahrung der einzigartigen Natur. Abgerundet und bereichert durch viele wertvolle Anregungen und praktische Tipps, lassen diese Reiseimpressionen – nachdenklich und humorvoll, unterhaltsam und informativ – auch Kennern noch neue Aspekte entdecken und stimmen Einsteiger auf ihren ersten Besuch der Seychellen ein. Willkommen im Paradies!