Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

Autori

• Colm Duffy

Serie

• Springer Theses

Parametri

• 152 pagine
• 6 ore di lettura

• Saggistica

Maggiori informazioni sul libro

Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.

Lingua: Inglese

Pubblicato: 2014

(In brossura)