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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.
Acquisto del libro
Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Lingua
- Pubblicato
- 2014
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- (In brossura)
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- Sottotitolo
- Synthesis and Biological Evaluation
- Lingua
- Inglese
- Autori
- Colm Duffy
- Editore
- Springer, Berlin
- Pubblicato
- 2014
- Formato
- In brossura
- Pagine
- 152
- ISBN13
- 9783642438929
- Serie
- Springer Theses
- Tag
- Saggistica
- Descrizione
- Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.
