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Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

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  • 152pagine
  • 6 ore di lettura

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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.

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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy

Lingua
Pubblicato
2014
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Metodi di pagamento

Sottotitolo
Synthesis and Biological Evaluation
Lingua
Inglese
Pubblicato
2014
Formato
In brossura
Pagine
152
ISBN13
9783642438929
Descrizione
Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.